Doctor's Best Comprehensive Prostate Formula 90 tabs
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Comprehensive Prostate Formula is a complete
nutritional program for supporting prostate health with herbs, vitamins,
minerals and other nutrients known to benefit the prostate gland.
Herbs:
Saw palmetto extract--The Saw palmetto in Comprehensive Prostate Formula is
standardized to contain 85 to 90% fatty acids, which are the active
ingredients in the Saw palmetto berry that promote prostate health. Three
tablets supplies 320 mg, the daily dose used for prostate therapy in
clinical studies.1
Pygeum extract--Pygeum is an evergreen tree native to the high plateaus
of southern Africa. Pygeum bark contains phytosterols, beta sitosterol and
other sitosterols, natural sterols that have been shown to normalize the
prostate.2 Clinical trials establish 100 mg per as a
highly effective dose of Pygeum extract, especially in combination with
Nettle root.3
Nettle root extract--Nettle, also known as "Stinging Nettle," grows wild
in forests and fields throughout North America and Europe. Nettle root has
been researched in European studies and shown to benefit the prostate and
urinary tract. While the specific active ingredients in Nettle for prostate
support have not been positively identified, Nettle's effect on the prostate
may stem from its content of polysaccharides and isolectin.4
300 mg per day is a clinically effective dose of Nettle root extract.3
Amino acids--The combination of L-alanine, glutamic acid and glycine were
first used for prostate support in 1958. Two medical doctors administered
the amino acids to allergy patients who reported improvement in urinary
function.5
Lycopene--Tomatoes are rich in carotenes, natural pigments responsible
for the rich variety of colors in fruits and vegetables. Lycopene gives the
tomato fruit its red color. Recent research suggests that lycopene may help
reduce the risk of prostate cancer.6 (These findings,
however, are strictly preliminary and await confirmation through further
research.)
Minerals--The human prostate contains a high concentration of zinc, which
is known to be a key mineral for prostate health.7
Selenium, an essential trace mineral, may play a role in cancer risk
reduction.8,9 Recent work by Harvard University
researchers showed that men with the highest levels of selenium were less
likely to develop prostate cancer than those with the lowest selenium
levels. Copper is added to balance zinc. When supplementing with zinc, it is
advised to take a small amount of additional copper to prevent copper
deficiency.
Vitamins--Vitamin E is added as an antioxidant and support for the
reproductive system. Vitamin B6 may benefit the prostate by reducing excess
levels of the hormone prolactin.10
Benefits
Helps maintain a healthy prostate gland.
Supports normal urinary function.
Comprehensive Prostate Formula-the Clinical Studies
Saw palmetto Extract
Saw palmetto extract is one of the world's leading herbal products for
prostate support. Widely-cited clinical studies conducted over the last
fifteen years suggest Saw palmetto extract can produce major improvements in
prostate-related urinary function. In clinical studies, Saw palmetto extract
has produced measurable improvements in urinary functions and prostate size.
Quality of life scores have also improved. The results with Saw palmetto
extract have been duplicated in open trials and controlled, double-blind
studies.11,12,13
For example, in a large open trial, 505 men took 320 mg of Saw palmetto
extract daily for three months.1 The results were
evaluated with various measurements such as the International Prostate
Symptom Score, the quality of life score, urinary flow rates, residual
urinary volume, and prostate size. After 45 days these parameters improved
significantly. After 90 days of treatment nearly ninety percent of both the
doctors and patients regarded Saw palmetto extract as effective as therapy
for the prostate.
The changes in prostate health that accompany middle age are related to
the hormone DHT, or dihydrotestosterone, a metabolite of testosterone. DHT
levels rise, and DHT binds to prostate cells, accelerating growth of
prostate tissue. Saw palmetto extract has been shown to inhibit 5 alpha-reductase,
an enzyme that controls conversion of testosterone to DHT.14
Experimental evidence suggests Saw palmetto extract blocks the binding of
DHT to prostate cells.15 The fatty acids and sterols
in Saw palmetto are believed to be responsible for these actions.14,16
These include oleic acid, lauric acid, campasterol, stigmasterol,
beta-sitosterol and others. Clinical studies have used extracts containing
85 to 90 percent fatty acids and sterols.
Pygeum Extract
Like Saw palmetto, Pygeum contains natural sterols and fatty acids.2
Although the mechanisms for its effect have not been clearly established,
animal experiments suggest Pygeum may work by inhibiting prostate cell
proliferation and reducing inflammation.17,18 In
several European trials, Pygeum has successfully improved urinary function.
In a large double-blind, placebo-controlled study, 263 men were given 100 mg
of Pygeum extract a day for 60 days. Urination improved in 66 percent of the
men taking Pygeum, compared with 31 percent on placebo, based on subjective
and objective tests.19
Nettle Root Extract
Nettles are approved by the German Commission E as effective for relieving
inflammation in the urinary tract.20 As far back as
1950, German investigators have observed favorable effects on the prostate
with the use of Nettle root. These initial findings have been confirmed
through case studies, as well as double-blind studies, published mainly in
German medical journals. In a recent double blind study published in the
journal Clinical Therapeutics, 134 men took a combination of Nettle root
extract and Pygeum extract over a period of 56 days.3
Urination was significantly improved.
L-Alanine, Glutamic Acid and Glycine
As noted above, Drs. Feinblatt and Gant discovered that a combination of the
amino acids L-alanine, glutamic acid and glycine has a positive effect on
prostate-related urinary function.5 A controlled study
of 45 men was conducted to follow up on these initial observations.21
The majority of subjects experienced complete or partial relief in
urinary complaints such as nighttime urination and urgency.
Safety
Suggested Use: As a dietary supplement, take 3 tablets daily.
Scientific References
1. Braeckman, J., 'The extract of Serenoa repens in the treatment of benign
prostatic hyperplasia: a multicenter open study,' Current Therapeutic
Research 1994: 55(7):776-85.
2. Lawrence Review of Natural Products. Pygeum. Jan 1998. Facts and
Comparisons, St. Louis, MO.
3. Combined extracts of Urtica dioica and Pygeum africanum in the treatment
of benign prostatic hyperplasia: double-blind comparison of two doses
Clinical Therapeutics 1993; 15(6):1011-19.
4. Wagner, H., Willer, F., Samtleben, R., Boos, G. Search for the
antiprostatic principle of stinging nettle (Urtica dioica) roots
Phytomedicine 1994; 1:213-224.
5. Feinblatt, H.M., Gant, J.D. Palliative treatment of benign prostatic
hypertrophy. Journal of the Maine Medical Association, March 1958:99-124.
6. Giovanni, E., et. al. Intake of carotenoids and retinol in relation to
risk of prostate cancer. Journal of the National Cancer Institute
1995;87(23):1767-76.
7. Wallace, A.M., Grant, J.K. Effect of zinc on androgen metabolism in the
human hyperplastic prostate. Biochemical Society Transactions 1975;
3(3):540-42
8. Badmaev, V., Majeed, M., Passwater, R. Selenium: A quest for better
understanding. Alternative Therapies 1996; 2(4):59-67.
9. Fouhad, M.T. Selenium and cancer, chromium and diabetes: two trace
elements that have merits as dietary supplements in human nutrition. Journal
of Applied Nutrition 1979:31(1&2):14-17.
11. Tasca, A., et. al. Treatment of obstructive symptomatology caused by
prostatic adenoma with an extract of Serenoa repens. Double-blind clinical
study vs. placebo. Minerva Urologica e Nefrologica 1985; 37:87-91.
12. Champault, G., Bonnard, A.M., Cauquil, J., Patel, J.C. Medical treatment
of prostatic adenoma. A controlled test of PA 109 vs. placebo in 110
patients. Ann. Urol. 1984; 18(6):407-410.
13. Crimi, A., Russo, A. The use of Serenoa repens extract in the treatment
of functional disturbances caused by prostate hypertrophy. Med. Praxis 1983;
4:47-51.
15. Sultan, C., et. al. Inhibition of androgen metabolism and binding of
liposterolic extract of Serenoa repens B in human foreskin fibroblasts. J.
Steroid Biochem. 1984; 20(1):515-519.
16. Weissner, H., et. al. Effects of the Sabal serrulata extract IDS 9 and
its subfractions on 5 alpha-reductase activity in human benign prostatic
hyperplasia. The Prostate 1996;28:300-06.
17. Yablonsky, F. Nicolas, V., Riffaud, J.P., Bellamy, F. Antiproliferative
effect of Pygeum africanum on rat prostatic fibroblasts. J. of Urology 1997;
157:2381-87.
18. Marconi, M. et. al. Anti-inflammatory action of Pygeum extract in the
rat. Farmaci. & Terapia. 1986; 3:135.
19. Barlet, A, et. al. Efficacy of Pygeum africanum extract in the treatment
of micturational disorders due to benign prostatic hyperplasia. Evaluation
of objective and subjective parameters. A multicenter, randomized,
double-blind trial. Wien. Klin. Wocheschr. 1990; 22:667-73.
20. The Complete German Commission E Monographs. 1998, Blumenthal, M., ed.,
(p.216) Austin, TX: American Botanical Council.
21. Damrau, F. Benign prostatic hypertrophy: amino acid therapy for
symptomatic relief. American Journal of Geriatrics 1962; 10:426-30.
*Above statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
