Benefits
Helps Maintain Normal Cholesterol Levels in Healthy Individuals* PMFs:
In Vitro and Animal Research
Research into the way in which PMFs modulate the production of
cholesterol has revealed potential mechanisms of action. One such in vitro
trial looked at the effect of tangeretin on human HepG2 cells, a model
commonly used to study the metabolism of lipids. This study found that when
these cells are exposed to tangeretin, the rate of Apoprotein B production
rapidly decreases.1 Apoprotein B is a structural
protein that controls the synthesis of LDL cholesterol from the cells. The
study showed that tangeretin inhibited apoprotein B secretion in a
dose-dependant manner.
Another interesting component that was measured in this study was
tangeretin's effectiveness in a lipid-rich environment. The cells were
bathed in the tangeretin solution in the presence of a high amount of fat.
In this environment, tangeretin possessed the same ability to decrease
apoprotein B secretion.1 It was thus shown that
tangeretin can be effective at modulating the production of cholesterol in a
variety of cellular environments.
The researchers also showed that tangeretin may modulate the production
of triglycerides on an enzymatic level. Triglycerides are an important
component of the body's lipid profile, and play a role in human health
similar to other cholesterol components. Microsomal triglyceride transfer
protein (MTP) and diacylglycerol acyltransferase (DGAT) are two components
of triglyceride synthesis and transport within the cells. Tangeretin
displayed inhibitory effects on MTP and suppressed the activity of DGAT,
thereby affecting triglyceride metabolism.1
A 2005 in vitro study looked at the effects of the second major PMF
present in Sytrinol , nobiletin. The results of this study showed that
nobiletin, in addition to being able to modulate the production of
cholesterol, has important free radical scavenging effects in the
bloodstream.2
It is well known that the levels of cholesterol in the bloodstream are
not the only factor in determining cardiovascular risk. Just as important,
if not more important, is the state of oxidation of LDL cholesterol
molecules. Oxidized LDL may deposit in blood vessels and increase
cardiovascular risk factors. Nobiletin was shown to prevent oxidative damage
to LDL molecules in this study.2 In purveying its
potent antioxidant effect, it keeps the LDL molecules healthy and prevents
them from causing potential harm.*
A recent trial was conducted in hamsters to measure the effectiveness of
a combination of tangeretin and nobiletin on serum cholesterol levels. This
controlled trial investigated the effect of including these PMFs into the
diet for 5 weeks. The control group received a normal, standardized diet
free of PMFs. Blood parameters were measured and at the end of the
experimental period, the animals fed the tangeretin/nobiletin combination
showed significantly favorable results in a number of lipid parameters.3
This research highlights the ability of these PMFs to have beneficial
effects on the maintenance of cardiovascular health.*
Tocotrienols: Research Summary
A number of studies have highlighted the cardiovascular health benefits
of tocotrienols. Animal studies have shown important serum lipid modulating
functions of various tocotrienols. A study conducted in rats found that
supplementation of their diets with gamma-tocotrienol resulted in
significant effects on total and LDL cholesterol levels after 6 weeks.4
A second study assessed the impact of feeding tocotrienol-rich rice
bran oil to chickens. The results also showed significant decreases in total
and LDL cholesterol levels.5
Additional in vitro and animal research has documented the far-reaching
benefits of tocotrienols on a number of cardiovascular markers. Some of the
most interesting research shows amazing antioxidant abilities of these
compounds, including an ability to protect LDL cholesterol molecules from
lipid peroxidation, thus preventing them from becoming harmful.6
This is also a noted effect of PMFs.
According to in vitro trials, tocotrienols work to modulate cholesterol
synthesis at the enzymatic level. This action is unique to these compounds
and researchers believe that this mechanism is responsible for the positive
results seen in the animal studies.6
Two human trials with tocotrienols have also shown positive results on
lipid profiles. Tocotrienol-rich palm oil or rice bran oil was used in these
studies and they both showed significant effects on plasma cholesterol
levels.6 The various mechanisms of action of
tocotrienols make them an ideal choice for promoting heart health.
Sytrinol : Human Clinical Trials
Sytrinol combines the benefits of PMFs and tocotrienols in one convenient
formula to promote cardiovascular health.* Two initial small clinical trials
were conducted to determine the effectiveness of this product at maintaining
healthy cholesterol levels already in the normal range.7
Both showed very positive results evidenced by a healthy impact on plasma
cholesterol, LDL and triglyceride levels. Based on these results a larger
clinical trial of 120 people was conducted with highly favorable results.
This trial is due for publication soon.7 The promising
results of this trial and prior research place Sytrinol as a safe and
effective cornerstone of cardiovascular health maintenance and wellness
protocols.*
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