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Celadrin® is a unique formulation of esterified
(stable) fatty acids that has been shown to reduce certain effects related
to pronounced inflammatory processes that can occur in the body. Being a
complex molecule consisting of various fatty acids, it is able to
penetrate cell membranes, which enhances membrane permeability and
cell-to-cell signaling. In doing so, Celadrin® may reduce the level of
inflammatory components of the immune system from binding to cells and
thus causing occasional inflammation in different parts of the body.1
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Benefits
Increased Range of Motion in Joints*
Research has shown that
Celadrin can have an impact on improving the range of motion in joints. A
placebo-controlled trial conducted in 2002 showed that those individuals
taking a complex containing Celadrin for 2 months had a significant
improvement in knee flexion (ability to bend the knee) over those taking a
placebo.1
Another study conducted
on Celadrin published in 2004 concluded that treatment “significantly
increased physical performance (as measured by a variety of orthopedic
tests)” in patients with compromised knee mobility. The study found that the
subjects given Celadrin showed improvement in their ability to climb stairs,
rise from a chair and walk, along with an improved sense of balance,
strength and endurance.3
Maintains Joint Comfort*
The anti-inflammatory
actions of Celadrin have been demonstrated by one double-blind, placebo
controlled trial that showed Celadrin, when taken orally at recommended
intake levels, decreased pain scores and increased walking distance compared
to the group receiving placebo. The authors theorize that Celadrin may work
by down-regulating the effect of certain precursors of the body’s
inflammatory response.1
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Scientific References
1. Hesslink R Jr., et al. Cetylated fatty acids improve
knee function in patients with osteoarthritis. J Rheumatology
2002;8:1708-1712.
2. Anonymous. Monograph: Glucosamine sulfate. Alt Med Review
1999;4:3;193-195.
3. Kraemer WJ, et al. Effect of a cetylated fatty acid topical cream on
functional mobility and quality of life of patients with osteoarthritis. J
Rheumatology 2004;4:767-74.
4. Crolle G, D'Este E. Glucosamine sulphate for the management of
arthrosis: a controlled clinical evaluation. Curr Med Res Opin
1980;7:104-109.
5. Rovati LC. Clinical research in osteoarthritis: design and results of
short-term and long-term trials with disease modifying drugs. Int J Tissue
React 1992;14:243-51.
Acting as a biochemical "super-thiamin," it does this through several
different cellular mechanisms, as discussed below.
6. Bassleer C, et al. Stimulation of proteoglycan production by
glucosamine sulfate in chondrocytes isolated from human osteoarthritic
articular cartilage in vitro. Osteoarthritis and Cartilage 1998;6:427-434.
Med. 2002 Oct 14;162(18):2113-23.
7. Reginster JY, et al. Long-term effects of glucosamine sulphate on
osteoarthritis progression: a randomized, placebo-controlled clinical
trial. Lancet 2001;357:251-56.
8. Macario, J. T., Rivera, I.C. Bignamini, A.A. Oral
glucosamine sulphate in the management of arthrosis: report on a
multi-centre open investigation in Portugal. Pharmatherpeutica 1982;
3(3):157-68.
9. Kraemer WJ, et al. Effect of acetylated fatty acid
topical cream on functional mobility and quality of life of patients with
osteoarthritis. J Rheumatol.2004 Apr;31(4):767-74.
10. Kraemer WJ,et al. Acetylated fatty acid topical
cream with menthol reduces pain and improves functional performance in
individuals with arthritis. J Strength Cond Res.2005 May;19(2):475-80.
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